About two years ago, one of our Pathfinder games was scheduled on a Friday night and it was our intent to play as long as possible. Which we did. Ended up playing about 16 hours on and off through the weekend.
We're all just about in our 40s and we're not made for that kind of abuse any more. Tempers ran high and tolerances were low. It ended with a falling out with a few members of our group for a while. Killed the campaign. We're all back together again now, but I don't think we'll be trying that stunt again. I don't recommend you do either.